Energy reserves of the brain during potassium embelate-induced antinociception in rat.

Certain analgesics are known to affect the metabolic status of the brain a~d other parts of the CNS, and in this respect most profound effects have been noticed in the intermediary metabolism of carbohydrates. A potassium salt of embelin (Ex: Embelia ribes) was reported to produce time dependent antinociception which begins-at 0-15 min, reaches maximum at 30m min and diminishes by 90 min (I). The purpose of present investigation has been to'fipd_ out the effect of potassium embelate on the energy status of the brain during these time pericds, viz, 0, 15, ~O, 60 and 90 min after the drug administration.